Shortfalls of CAR-T in Solid Tumor
Inadequate numbers of effective CAR-T cells quickly lose activity
Numbers
Cancer cells significantly outnumber a physiological restricted CAR-T cells
Battlefield
TME and other factors hampers CAR-T cell quantity and further undermine the longevity and efficacy of CAR-T cells
Mechanisms
Attempts to improve CAR-T cells all restricted by the nature of using costimulatory and ITAM
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